Acute liver failure

Rapid decrease in liver function

Drugs, toxins, a variety of liver diseases

Autoimmune-associated

The body produces an inappropriate immune response against itself; sometimes develops antibodies against own liver tissue

PBC (Primary biliary cirrhosis), PSC (Primary sclerosing cholangitis), Autoimmune hepatitis

Budd-Chiari syndrome

Blood clots impede blood flow from the liver; symptoms such as ascites, enlarged liver, jaundice, and abdominal pain can develop

Hypercoagulable disorders, liver injury, cancer,parasitic infection

Cirrhosis

Scarring of liver tissue leads to decreased liver function

Can be caused by a variety of conditions but usually a result of chronic hepatitis, alcoholism, or chronic bile duct obstruction

Genetic

Gene mutations can lead to liver damage, disease; relatively rare conditions

Hemochromatosis, Alpha-1 antitrypsin deficiency, Wilson's disease

Hepatitis

Acute or chronic liver inflammation

Viruses, alcohol abuse, drugs, toxins, autoimmune, nonalcoholic fatty liver disease (NAFLD)

Infections

Certain infections can cause various degrees of liver damage, blockage of bile ducts

Viral hepatitis, Parasitic infection

Liver cancer

A cancer that originates in the liver

Increased risk with cirrhosis and chronic hepatitis; hepatocellular carcinoma (HCC) is most common primary liver tumor

Obstruction of bile ducts

Complete or partial blockage of bile ducts

Tumors, gallstones, inflammation, trauma